Nitrofurantoin is the only recommended first-line antibiotic used for treating cystitis in the UK. It's often sold under different brand names such as Macrobid, but these medications all contain the same active ingredients and work in the same way by killing the bacteria causing the infection.
You can order Nitrofurantoin quickly and simply from our online doctors. All you need to do is:
- Press start order and fill in a short medical questionnaire
- A doctor will review your answers to make sure it's right for you
- Our doctors will post it directly to your door, or you can collect it from your nearest post office
You can also message a doctor at any time through your patient account if you have any questions about Nitrofurantoin or your health.
A course of Nitrofurantoin capsules to treat a bladder infection will usually be three days, and you will need to take one capsule in the morning and evening.
So, if you're concerned about a bladder infection or worried you might have cystitis, Nitrofurantoin might be the perfect treatment for you.
Read on to learn more about Nitrofurantoin, how it works and how to take it.
6 capsule(s) - £22.00
Aratoin, MacroBid, MicroDantin, FuraDantin, and generic nitrofurantoin capsules all contain the active ingredient: nitrofurantoin.
The other ingredients in the MacroBid capsules offered by ZAVA:
- Maize starch
- Lactose monohydrate
- Sodium lauryl sulphate
- Quinoline yellow (E104)
- Titanium dioxide (E171)
- Black iron oxide (E172)
Like all medications, you may get side effects while taking nitrofurantoin. Common ones to look out for are:
- feeling sick (nausea) or being sick (vomiting)
- loose stools or diarrhoea
- loss of appetite
- stomach ache
- a skin rash
- a dark yellow or brown urine
Nitrofurantoin comes in capsules that are taken orally (by mouth). They are a type of antibiotic which is used to help your body recover from an infection by killing bacteria or stopping them growing.
Nitrofurantoin is most commonly used to treat cystitis, also known as urinary tract infections (UTI) or a bladder infection.
A lower dosage of nitrofurantoin can also be used to prevent cystitis from happening. It’s normally used in this way in people who get more than three episodes, or outbreaks, of cystitis in a year. At ZAVA we only offer nitrofurantoin to treat current cystitis infections and not for preventing future infections.
Nitrofurantoin is also used to prevent infections in people who are having surgery on their bladder or reproductive system.
Always take nitrofurantoin exactly as you’ve been told by a doctor or pharmacist. If you’re not sure, read the information leaflet that comes with the medication.
The dosage of nitrofurantoin that you take depends on what condition you have. The dosage that you’re taking is always written on the outside of the box of nitrofurantoin. The dosage to treat cystitis is one 100mg capsule twice a day for 3 days.
To take nitrofurantoin, you should swallow a capsule whole with a glass of water or milk. Don’t chew or open the capsule.
If you forget a dose, just take the dose as soon as you remember, unless it’s nearly time for your next dose. If it’s nearly time for your next dose, just skip the dose you forgot. Don’t take more than one dose to make up for a forgotten one.
If you find it difficult to remember all of your doses of nitrofurantoin, you could set alarms on your phone to remind you. Or, you can pair taking nitrofurantoin with a task that you do every day. For example, you can take nitrofurantoin after you brush your teeth.
Accidentally taking more nitrofurantoin than you should is unlikely to cause you harm. But, speak to a doctor or pharmacist if you:
- took more than one extra dose
- are getting severe side effects
- are otherwise worried
If you speak to a doctor or pharmacist in person, make sure you take the packet of nitrofurantoin with you and let them know how much nitrofurantoin you’ve taken and the time that you took it.
Nitrofurantoin helps the body fight off cystitis by killing the bacteria that are responsible for the infection.
After you take nitrofurantoin, your body starts to process the medication by absorbing it into your blood. It then gets filtered by the kidneys into the bladder, putting the medication close to the bacteria that cause cystitis.
Once it’s in the bladder, nitrofurantoin gets inside the bacterial cells and damages their genes (DNA). This kills the bacteria and helps the body get rid of the infection.
Treatment with nitrofurantoin is suitable for you if you:
- have cystitis and you’re a woman, not pregnant, and don’t currently have a small tube inserted to remove urine from the body (catheter)
- have had more than three episodes of cystitis in a year and would like to take nitrofurantoin to prevent another episode from happening. This service is not offered at ZAVA
- are going to have surgery to your bladder or your reproductive system. This service is also not offered at ZAVA
You shouldn’t take nitrofurantoin if you:
- have a blood disorder called acute porphyria
- have a genetic disorder called G6PD deficiency
Speak to a doctor before taking nitrofurantoin if you:
- have been told you have anaemia
- have diabetes
- have a deficiency of folate
- have pulmonary disease
- are at risk of getting peripheral neuropathy
Nitrofurantoin is a safe and effective medication to use during most of the time you’re pregnant.
Taking nitrofurantoin when you’re pregnant doesn’t put your baby at a higher risk of negative consequences, like birth defects, stillbirth, low birth weight, or premature birth.
Taking nitrofurantoin when you’re between 38 and 42 weeks pregnant could put your baby at risk of jaundice (yellowing of the skin and eyes). This condition can get better on its own after a few weeks, or it can be treated by light therapy if it’s more severe. So, it can be good to avoid nitrofurantoin if you’re at this stage of pregnancy.
Nitrofurantoin can interact with other medicines. Speak to your doctor before taking nitrofurantoin if you’re also taking:
- Dapsone: this medication is used to treat a certain skin condition called dermatitis herpetiformis
- Prilocaine: this medication is used as a local anaesthetic and to treat long-term pins and needles (parasthesia)
Nitrofurantoin doesn’t react with alcohol. But, we don’t recommend drinking too much alcohol if you have cystitis, because alcohol may make your symptoms worse.
Like with all medications, nitrofurantoin might cause some side effects. There are some things that you can do to help you cope with side effects if you get them:
- Eat light, plain meals if you’re having an upset stomach with nitrofurantoin
- Don’t drive if you find that you get drowsy or dizzy after taking nitrofurantoin
Allergic reactions are a rare but serious side effect of taking nitrofurantoin. Go to your nearest A&E department straight away if you get any of these symptoms:
- Swelling of the face, lips, and tongue
- A raised, itchy rash over your whole body (hives)
- Wheezing or difficulty breathing
Dr Nicholas Antonakopoulos
Dr Nicholas Antonakopoulos graduated from the University of London in 2006. He did his postgraduate training in hospitals in the London area, and he trained for four years in Trauma and Orthopaedic Surgery before completing his training in General practice in 2015.Meet our doctors
Last reviewed: 04 Apr 2019
ADVANZ Pharma (2018). Nitrofurantoin 100mg capsules. EMC. [online] Available at: https://www.medicines.org.uk/emc/product/428/smpc [accessed 28th February 2019].
American College of Obstetricians and Gynecologists (2011). Sulfonamides, nitrofurantoin, and risk of birth defects. Committee Opinion No. 494. Obstetrics and Gynecology; 117: 1484-5. [online] Available at: https://pubmed.ncbi.nlm.nih.gov/21606771/. [accessed 13th May 2021]
BNF. Nitrofurantoin. NICE. [online] Available at: https://bnf.nice.org.uk/drug/nitrofurantoin.html [accessed 28th February 2019].
MercuryPharma (2018). Nitrofurantoin 50mg and 100mg capsules, hard. [online] Available from: https://www.medicines.org.uk/emc/files/pil.428.pdf [Accessed on: 13th March 2019].
McOsker, C. C. and Fitzpatrick, P. M. (1990). Nitrofurantoin: mechanism of action and implications for resistance development in common uropathogens. Journal of antimicrobial chemotherapy; 33(A): 23-30. [online] Available at: https://pubmed.ncbi.nlm.nih.gov/7928834/. [accessed 13th May 2021]