Genital Herpes Treatment
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Genital herpes treatment is used to help manage symptoms of the viral sexually transmitted infection (STI) called genital herpes, which causes blisters and sores on or around the genitals. There is no cure for genital herpes, but the symptoms can be treated. Genital herpes is typically treated with antiviral medications like aciclovir, valaciclovir, and famciclovir. If left untreated, genital herpes can cause long-term problems.
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About Genital Herpes Treatment
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Genital herpes is a sexually transmitted viral infection (STI) which is spread through vaginal, oral, and anal sex. It is caused by a common virus called the herpes simplex virus (HSV) which often appears through outbreaks and causes symptoms like a red blistered rash. In many cases, genital herpes is symptomless.
How does genital herpes spread?
Genital herpes can be spread by:
- unprotected sex
- skin contact with infected areas
- skin contact with areas where herpes blisters or sores are not visible
- the infection being carried on skin, such as fingers or hands, from someone else’s genitals to yours
- using sex toys used by someone who has herpes
- a cold sore coming into contact with your genitals
While genital herpes virus is contagious and easily transmittable from skin to skin, there is no risk of getting it from surfaces such as tables, door knobs, and toilet seats.
How common is genital herpes?
HSV, the virus which causes herpes, is very common. HSV is split into HSV-1 and HSV-2 types. HSV-2 causes genital herpes and a recent study from 2022 estimated that around 12.4% of the European general population have been exposed to this virus. However, not everyone with HSV-2 shows symptoms, so it is important to get tested not only if you have symptoms but also if you think you may be infected.
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The main symptoms of genital herpes are blisters which burst open and leave you with sores. They are usually red but can appear differently on black or brown skin and occur around the genitals, thighs, bottom or anus.
Other genital symptoms may include:
- pain when taking a pee
- tingling sensation
- itching or burning around the genital areas
- unusual discharge
When you first contract HSV-2 in your genital area it is called the primary infection. The first outbreak symptoms after exposure to the virus are usually the worst and outbreaks after are usually milder.
How often does genital herpes flare up?
Clinical studies have found patients experiencing 6 to 10 recurrences of genital herpes within a year after first exposure to the virus. However, this can vary from person to person, some may experience less recurrence, it depends on how regularly you are exposed to triggers.
For example, if you get an outbreak of genital herpes blisters and sores, these symptoms may come back because the virus lays dormant in your body until it is ‘activated’ by triggers which cause symptoms to appear.
Triggers may include:
- friction on and around your genitals, for example, from tight clothing or sex
- alcohol
- smoking
- ultra-violet light, such as sunbeds or sunbathing
- being ill
- being stressed
- genital surgery
- hormone changes during your menstrual cycle
- having a weakened immune system
Triggers will vary from person to person and it is important to understand what triggers your outbreaks so you can try to avoid them where possible. However, some triggers are unavoidable and there are medications available to help manage outbreaks.
What does genital herpes look like?
Genital herpes looks like bumps or blisters which are yellow or clear and filled with a clear liquid. It is important to get the correct diagnosis and treatment. If you’re unsure whether you are experiencing genital herpes or another condition, you should get examined by a doctor at a sexual health clinic or your GP.
Can genital herpes be mistaken for other conditions?
Genital herpes is sometimes mistaken for other conditions such as:
- STIs that cause visible sores or lesions like genital warts or syphilis
- a urinary infection
- irritation from shaving or ingrown hairs
- insect bites
- pimples
- haemorrhoids (piles)
- yeast infections
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Genital herpes can be diagnosed by taking a swab of a sore or blister and sending it to a lab for testing. You can do this at home, using a genital herpes home test kit or you can visit your local sexual health clinic. This does mean you need to have symptoms at the time of testing.
To take an at-home test you just need to rub the swab onto one of your genital blisters or sores, then put it into a test tube and send it to the lab for testing. You will not need to see a doctor. If you get a positive diagnosis, you can then get treatment to manage your symptoms or to prevent further outbreaks.
Our swab test kits are just as accurate as those used by doctors at a sexual health clinic and you can order the kit to be delivered straight to your door in discreet packaging, or for collection at your local Post Office.
When should you get tested for genital herpes?
Get tested right away if you have previously been exposed to genital herpes and think you may be experiencing an outbreak.
If you think you might have it but have no symptoms, wait for up to 12 days to take a test. The incubation period (time it takes for the virus to develop in the body) of genital herpes is between 2 to 12 days, but some people exposed to the virus may not experience symptoms for months.
You should only take a swab test if you have symptoms. You can speak to your GP about taking a blood test to check for herpes if you had an outbreak and did not get tested at the time you had symptoms. It is important to get tested if you think you may have been exposed to the virus. If genital herpes is left untreated it can cause long-term complications.
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Genital herpes can be treated with several different antiviral medications which work to stop the herpes virus from multiplying and manage outbreaks by controlling the infection and allowing your immune system to deal with it.
The most common antiviral treatments for genital herpes are:
How effective is genital herpes treatment?
Studies have found that suppressive treatment for genital herpes with antiviral medications like aciclovir, valaciclovir and famciclovir minimise recurrent outbreaks by 70 to 80% in a year. These treatments tend to stop outbreaks within a few days if taken promptly when symptoms begin and must be taken as prescribed and advised by your doctor.
How to take genital herpes treatment
Your genital herpes medication is in the form of an oral tablet and should be taken whole with water. The dosage you’ll need to take will depend on exactly which medication you are prescribed and what stage of your infection you take it. Genital herpes medication can be prescribed to suppress outbreaks if you get them often.
Check carefully with your doctor and read the patient information leaflet provided to ensure you are using the medication correctly. Here’s a quick summary of how often you’ll typically take each treatment:
Aciclovir: Usually taken 5 times daily for 5 to 10 days during an outbreak.
Valaciclovir: Usually taken twice daily for 5 to 10 days during an outbreak.
Famciclovir: Usually taken twice daily for 5 to 10 days during an outbreak.
For long-term suppression of frequent outbreaks, your doctor may prescribe a lower daily dose for an extended period. Always follow your doctor’s advice for the exact dosage and duration.
Is there a cure for genital herpes?
There is no cure for genital herpes. The virus will remain in your body and outbreaks might occur again, but how often this happens is different from person to person. However, the symptoms can be managed if you take prescribed antiviral medications.
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Yes, you can order genital herpes treatment online from reputable, safe and regulated online doctor services like ZAVA. We provide a fast home delivery service with discreet packaging, and our services include both test kits and antiviral medication to treat genital herpes.
Getting genital herpes treatment or testing from ZAVA is quick and convenient, with no need for a face-to-face appointment. Simply:
- Complete a short online medical questionnaire – share details about your health so our doctors can ensure the treatment or testing is right for you.
- Order and pay online – sign in or create your ZAVA account, select ‘Genital Herpes Treatment’, and securely make your payment.
- Doctor review and approval – a UK-licensed doctor will check your health information and approve your prescription if the treatment is safe and appropriate for you.
- Fast and discreet delivery – if approved, your selected treatment will be delivered discreetly to your home or a local post office for collection.
Can I get genital herpes treatment over the counter?
No, antiviral medications suitable for treating genital herpes are not available over the counter. They are prescription-only.
Can I get genital herpes treatment on the NHS?
Yes, you can get NHS treatment for genital herpes from sexual health clinics and your local GP. Accessing treatment will require you to have a consultation in person and you may have to pay for your prescription.
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Below is a list of common side effects for the three main treatments for genital herpes. The side effects you may experience depend on the medication and dosage prescribed.
Aciclovir
Common side effects (may affect up to 1 in 10 people):
- headache
- feeling dizzy
- feeling or being sick
- diarrhoea
- stomach pains
- rash
- skin reaction after exposure to light
- itching
- feeling tired
- a fever (high temperature) which is unexplained
- feeling faint, especially when standing up
For a full list of side effects, including those which are uncommon or rare please refer to the aciclovir patient information leaflet.
Valaciclovir
Very common side effects (may affect more than 1 in 10 people):
- headache
Common side effects (may affect up to 1 in 10 people):
- feeling sick
- dizziness
- vomiting
- diarrhoea
- skin reaction after exposure to sunlight
- rash
- itching
For a full list of side effects, including those which are uncommon or rare please refer to the valaciclovir patient information leaflet.
Famciclovir
Very common side effects (may affect more than 1 in 10 people):
- headache
Common side effects (may affect up to 1 in 10 people):
- feeling sick (nausea)
- vomiting
- diarrhoea
- stomach pain
- feeling dizzy
- skin reaction, such as rash or itching
- abnormal liver function test results
For a full list of side effects, including those which are uncommon or rare, please refer to the famciclovir patient information leaflet.
There are many potential side effects with genital herpes treatments, although not everyone gets them. The side effects that you may get will depend on the specific medication and dose you are prescribed. It is important to read the list of potential side effects in the patient information leaflet provided before taking genital herpes medication.
What to do if you get genital herpes treatment side effects
If you get any side effects from genital herpes treatment it is important you talk to your doctor as soon as possible. There are often simple ways to manage side effects, such as taking over-the-counter painkillers or eating food with your dose if it makes you feel nauseous.
In the event of serious side effects, such as an allergic reaction, you may get symptoms such as:
- difficulty breathing
- swelling of the face, lips, tongue, or throat
If you get these serious side effects, seek immediate medical attention by calling 999 or going to your nearest A&E.
For less urgent concerns or advice, you can call 111 to speak to a healthcare professional.
If you notice any side effects not listed in the patient information leaflet, consult your doctor or pharmacist for further advice.

Brenda studied medicine at St Georges University of London and has most recently worked in John Radcliffe Oxford University Hospitals, covering acute and general medicine.
Meet our doctorsLast reviewed: 30 Jan 2025
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Herpes sinplex - genital, NICE/Clinical Knowledge Summaries [accessed 29 January 2025]
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Genital herpes, NHS [accessed 29 January 2025]
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Aciclovir, NICE/British National Formulary [accessed 29 January 2025]
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Valaciclovir, NICE/British National Formulary [accessed 29 January 2025]
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Famciclovir, NICE/British National Formulary [accessed 29 January 2025]