Oxytetracycline and Epiduo

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Oxytetracycline tablets and Epiduo gel
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Prices from £99.00

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Oxytetracycline 250mg and Epiduo 0.1/2.5 % w/w

3 month course / Oxytetracycline, 336 tablets and Epiduo, 45 g - £99.00

How should I take oxytetracycline and Epiduo?

Most importantly, you need to take oxytetracycline as your doctor advises. You should take tablets one hour before or two hours after a meal. You need to swallow the tablet whole with a full glass of water. You should not take the tablets just before you go to bed.

To treat acne the recommended dose of oxytetracycline is two tablets of 250mg, twice a day. It can take up to 8 weeks to see the full benefits of the medication so we recommend that you continue for at least this time. Usually treatment will be reviewed at 3 months to see if it should be stopped or continued.

If you overdose, seek medical assistance immediately.

If you forget to take a tablet, take it as soon as you remember. If this is near the time or your next due dosage, do not double dose, but skip the missed dose and continue as normal. You should try not to take oxytetracycline with food or milk, as they can make the treatment less effective.

To take Epiduo, apply a thin layer of gel to your symptoms once a day.


The active substance is oxytetracycline dehydrate (250mg or 500mg depending on the dosage of the tablet). The other ingredients in the tablet are magnesium stearate, maize starch, hydroxypropyl cellulose (E463), colloidal silica, sodium lauryl sulphate, propylene glycol, sunset yellow (E110), quinoline yellow (E104), titanium dioxide (E171), methylhydroxypropyl cellulose (E464) and purified talc (E553).

Epiduo’s active ingredients are adapalene and benzoyl peroxide. Epiduo also contains disodium edetate, docusate sodium, glycerol, poloxamer, propylene glycol (E1520), simulgel 600PHA, and purified water.

Do I need a prescription?

Yes. You can get this from your doctor or online at ZAVA.

What do the tablets look like?

The tablets are yellow, circular and biconvex.

Oxytetracycline and Epiduo side effects

If you get any of the following side effects, seek medical assistance:

  • Allergic reaction (swollen lips and face, itchy skin, difficulty breathing)
  • Symptoms of raised pressure in the skull (headache, visual problems, blurred vision, blind spots, double vision)
  • High sensitivity to sunlight

You should tell your doctor if you experience any of the following oxytetracycline side effects:

  • Vomiting
  • Diarrhoea
  • Discolouration of teeth
  • Difficulty swallowing
  • Swelling of the gullet
  • Loss of appetite
  • Redness of the skin, flaky skin
  • Thrush or irritation round anus and genitals

Common Epiduo side effects include:

  • a skin rash on the areas that you’ve used Epiduo
  • redness, irritation, or burning sensation where you’ve used Epiduo
  • dry or scaly skin

If you experience any of these side effects or any others, talk to your doctor.

Medically reviewed by:
Dr Kathryn Basford Accreditations: MB, ChB, MPH

Dr Kathryn Basford is a qualified GP who works as a GP in London, as well as with ZAVA. She graduated from the University of Manchester and completed her GP training through Whipps Cross Hospital in London.

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Last reviewed: 27 Apr 2019

ZAVA offers a range of options to manage acne symptoms, including antibiotics, anti-inflammatories for inflamed skin, and combination treatments that include Zinc to help skin repair.

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