Kliovance Tablets

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84 pack of Kliovance 1/0.5mg estradiol/norethisterone acetate film-coated tablets
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1/0.5 mg

84 days / 84 tablet - £35.00


Common side effects of Kliovance

  • Headache
  • Weight gain caused by fluid retention
  • Vaginal inflammation
  • Migraine, new or worse than before
  • Vaginal infection with a fungus
  • Depression, new or worse than before
  • Nausea
  • Enlargement or swelling of the breasts (breast oedema)
  • Back pain
  • Uterine fibroid (benign tumour), aggravation, occurrence or reoccurrence
  • Swelling of arms and legs (peripheral oedema)
  • Weight increase

Advice for Kliovance treatment

  • You need to talk to your physician if you have premature (early) menopause, which could have occurred because of ovarian surgery/failure.
  • Before you start (or resume) Kliovance (as part of hormone replacement therapy), you should let your physician know about your own and your family's medical history. Depending on this, your physician might decide it’s best to perform a physical examination, which could include an examination of your breasts and/or even an internal examination.
  • Once you’ve started taking Kliovance, you should see your physician for regular check-ups – you can ask them about how often these should be and schedule these in advance to help you keep track of these

Alternatives to Kliovance

Tibolone – this is similar to the combined HRT (oestrogen and progestogen) and it's taken as a tablet once a day. It can help relieve symptoms of menopause but there have also been some studies suggesting that combined HRT is more effective than this. Its side effects can include pelvic pain, abdominal pain, breast tenderness and vaginal discharge. It also has similar risks to HRT, including an increased risk of breast cancer and strokes.

Clonidine – this can help reduce some symptoms of menopause and is taken as tablets 2-3 times a day, with effects seen at roughly 2-4 weeks. It doesn't affect hormone levels or cause an increased risk of breast cancer but there’s some research to suggest it only has a very small effect on menopausal symptoms. Its side effects can include depression, drowsiness and constipation.

Herbal remedies – these aren’t recommended or guarenteed as a safe alternative, since there aren’t any medical authorities regulating these. This means that it’s hard to tell how effective, pure and/or strong each one is. Some can even cause quite severe side effects and interact with other medications.

Lifestyle changes – the following lifestyle changes could help with relieving some menopausal symptoms:

  • Exercise regularly – this can reduce hot flushes and improve sleep. It can also boost your mood if you feel anxious, irritable or depressed. Exercises involving weights can also be good to keep your bones strong
  • Follow a healthy diet – this can help you maintain a healthy weight and keep your bones healthy. Cutting down on caffeine, alcohol and spicy food is also a good idea since these have all been known to trigger hot flushes
  • Wear loose clothes – this can help you stay cool at night, but it also helps if you sleep in a cool, well-ventilated room if you experience hot flushes and night sweats
  • Try to reduce your stress levels – to improve mood swings, make sure you get plenty of rest, as well as getting regular exercise. Activities such as yoga and tai chi may help you relax
  • Give up smoking – giving up is generally good for your help but can also specifically reduce hot flushes
  • Use vaginal lubricant – this can help with the discomfort of vaginal dryness and there are a lot of types in shops and pharmacies


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