Emtricitabine/Tenofovir (PrEP)

Emtricitabine/tenofovir is a medication that’s used to control HIV. The name refers to its 2 active ingredients. It’s taken as a pre-exposure prophylaxis (PrEP) to prevent those with a high risk of exposure to HIV from catching it.

Emtricitabine/tenofovir does not cure HIV although it can be used as part of treatment for those with HIV to prevent the infection spreading further.

To request emtricitabine/tenofovir, start by completing our our online medical questionnaire.

What is Truvada?

Truvada is a branded version of emtricitabine/tenofovir. It's most commonly available in the US. The unbranded ‘generic PrEP’ we offer is typically prescribed in the UK.

Both Truvada and ‘generic PrEP’ contain the same active ingredients and are equally effective in preventing HIV.

Emtricitabine/tenofovir are antiviral drugs that work by protecting the body’s immune cells from HIV. The medication stops the virus from growing and spreading to other body cells.

Emtricitabine/tenofovir has been found to be highly effective for preventing HIV infection when taken as instructed.

Is emtricitabine/tenofovir effective after exposure?

If you’ve been exposed to HIV, and you’re taking PrEP as prescribed, you should be protected from the virus.

If you’re not currently taking PrEP and you think you’ve been exposed to HIV, you may need to start taking PEP (post-exposure prophylaxis) instead, not PrEP.

You should visit your local sexual health clinic for this. If it’s outside of normal working hours, go to your local A&E department instead.

Is emtricitabine/tenofovir safer than condoms?

Emtricitabine/tenofovir only protects you from HIV. Using a condom is a much safer option as condoms offer protection from a range of STIs, as well as HIV.

It’s recommended that you get tested for STIs every 3 months, including an HIV test.

Is undetectable HIV safe?

Studies have shown that people with an undetectable HIV viral load cannot pass on the virus to others. An ‘undetectable viral load’ means that the amount of the virus in their blood is not able to be found.

The PARTNER 2 study found that people taking effective HIV treatment with an undetectable viral load, did not pass on the virus to their sexual partners.

We can prescribe emtricitabine/tenofovir to you if you are over 18 years old, have tested HIV negative, and have a higher risk of getting HIV. Our doctors will check that treatment is suitable for you.

Scroll up to check if you have a higher risk of exposure to HIV.

Who should not take emtricitabine/tenofovir?

If you have a low risk of getting HIV, you do not need to take emtricitabine/tenofovir.

If you are HIV positive, you should not take emtricitabine/tenofovir on its own as you may develop resistance to full HIV treatment.

It may also be unsuitable to take emtricitabine/tenofovir if:

• you’re under 18 years old
• you have liver disease
• you have kidney disease
• you have an allergy to any of the ingredients in emtricitabine/tenofovir
• you’re taking any other type of antiviral medication
• you’re taking a regular high dose of painkillers
• you have any rare conditions relating to lactose intolerance
• you’re on a low phosphate diet
• you’re pregnant, breastfeeding, or trying to have a baby

If you fall into any of these categories but you have a high risk of HIV exposure, talk to a doctor. They can tell you about appropriate ways to protect yourself.

We provide a full PrEP therapy service without having to book a face to face appointment.

• To request PrEP, simply complete our online questionnaire. Our doctors can prescribe PrEP using the information you provide here. They will contact you via your account if they need any more information. If you have a question, you can message them for free too.
• Order any PrEP test kits you need to check your HIV, kidney function, or hepatitis status, through us. You can also order an STI test kit to check for sexually transmitted infections. Once you have your test kit, collect your sample yourself at home and send this away for analysis and results.
• Our doctors will be in touch with you while you’re taking PrEP. They can share any further advice that might be helpful. This includes regular reminders about tests and medication that you need to keep updated.

Before you begin taking emtricitabine/tenofovir, our doctors will check whether you’ve had:

• a negative HIV test result
• a normal kidney function test result
• a negative hepatitis B and C test result — you only need a negative hepatitis B result if you’ve not had a hepatitis B vaccination, and you only need a negative hepatitis C result if you are a man who has sex with other men or are a trans woman

We will ask about these tests when you complete our online questionnaire to request treatment. You can still request emtricitabine/tenofovir if you haven’t had one or more of these PrEP tests yet, but you must complete these before you begin using PrEP.

Once you begin taking PrEP, you will need to repeat these tests at different periods too.

Why are these tests important?

HIV test

It may be unsafe to take PrEP if you’re HIV positive. The antiviral drugs in PrEP (emtricitabine and tenofovir) are often used to treat people with HIV, alongside other medications. You can become resistant to these drugs if you use them when you’re already HIV positive. This can make it more challenging to treat the infection later on.

If you have flu-like symptoms after unprotected sex, like a fever or a rash, you should check that you’re HIV negative before taking PrEP. You may need to take PEP instead. Scroll up to learn more (‘Is emtricitabine/tenofovir effective after exposure?’).

Different HIV tests have different timeframes for testing after unprotected sex. Follow the instructions for your chosen test to make sure the results are accurate.

Our HIV test kit is over 99% accurate at detecting HIV if you test 6 weeks after possible exposure to HIV. You can test any time before that, but if you get a negative result, you should repeat your test to make sure your results are accurate.

Kidney function

The two antiviral drugs in PrEP are used by the body and then passed out in your urine through your kidneys. You need to check that your kidneys are working properly otherwise these drugs can build up in your body and cause damage.

Hepatitis B and C

If you have hepatitis, taking and subsequently stopping PrEP can lead to a flare up of liver inflammation and your hepatitis getting worse. It can also affect any future hepatitis treatment you receive and make it harder to treat your condition.

We prescribe emtricitabine/tenofovir to be taken daily, preferably with food at the same time each day. It's important to take it as prescribed by your doctor.

If your PrEP request is approved, carefully read the patient information leaflet that’s included with your medication once you receive this. Do this before taking emtricitabine/tenofovir for the first time.

What dose of emtricitabine/tenofovir should you take?

We offer 200mg emtricitabine and 245mg tenofovir, to be taken daily. These are provided together (i.e. you do not need to request these separately).

How long does emtricitabine/tenofovir take to work?

It takes about 4 days for emtricitabine/tenofovir to start working in men and up to 7 days for women.

How long does emtricitabine/tenofovir stay in your system?

It’s not yet known exactly how long emtricitabine/tenofovir can stay in the body after stopping PrEP therapy, but research has estimated that it stays for up to 7 days.

What should you do if you miss a dose of emtricitabine/tenofovir?

If you forget to take your emtricitabine/tenofovir tablet for the day but you remember within 12 hours of when you normally take it, you can still take it. If you remember after 12 hours, skip that day’s dose and take it as usual the next day.

What should you do if you take too much emtricitabine/tenofovir?

If you take more than your prescribed emtricitabine/tenofovir dose, go to your nearest sexual health clinic, or call 111.

Can you drink alcohol while taking emtricitabine/tenofovir?

Emtricitabine/tenofovir is not known to cause any interactions with alcohol, so you can still drink while taking it.

Can you take emtricitabine/tenofovir with other medications?

It’s important to tell your doctor about any medicines you’re taking before you start on a course of emtricitabine/tenofovir. This includes any over-the-counter drugs. We will ask about these when you complete our online questionnaire to order emtricitabine/tenofovir.

Some medications may affect emtricitabine/tenofovir and cause problems with your kidneys. Talk to your doctor if you’re taking:

• any drugs for treating fungal infections
• any drugs for treating viral infections
• antibiotics
• painkillers like Ibuprofen
• medications for treating hepatitis C
• cancer drugs

As with all medicines, emtricitabine/tenofovir can have side effects. These usually go away within a few weeks. Most people don’t experience any side effects.

Common side effects of emtricitabine/tenofovir include:

• feeling sick and being sick (vomiting)
• diarrhoea
• headaches
• dizziness
• feeling weak
• pain in the stomach
• feeling bloated
• problems with sleeping
• rashes or swelling of the skin

Less common side effects include:

• anaemia (a lack of red blood cells, or haemoglobin, in the blood)
• muscle weakness and pain
• yellow and itchy eyes
• pain in the bones
• joint stiffness
• back pain
• a condition called lactic acidosis where lactic acid builds up in the body causing drowsiness and difficulty with breathing

If you experience any serious side effects, you should go to A&E immediately.

We offer further information about the following areas of HIV. We cover:

• symptoms of HIV
• HIV skin rashes
• HIV testing and HIV test kits

The NHS has information on:

• HIV and AIDs

Terrence Higgins Trust provides information on:

• HIV therapy, support, and counselling

Naz offers information and support around:

• sexual healthcare to Black Asian and Minority Ethnic (BAME) communities

Depending on your background and circumstances, you can find more information:

• if you’re transgender through Mermaids
• about psychological therapies through the NHS
• about HIV prevention and works to fight against HIV stigma through the Gay men’s health project
• on drugs and chemsex from your local sexual health clinic or on Dean Street Clinic’s website

Several sources provide more information about PrEP and how it’s used. These include:

• iwantPrEPnow
• Prepster
• The PrEP Facts Facebook group