Foundayo (Orforglipron)

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Foundayo is a daily weight loss pill containing orforglipron that helps you lose weight by reducing your appetite.

  • First non-peptide GLP-1 weight loss pill to be approved
  • No fasting rules
  • Needle-free alternative to weekly injections

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Suitability for any medication for this service will be our doctors' medical decision based on your consultation.

About Foundayo pills

  • 12.4% average weight loss in 72 weeks

  • Contains orforglipron, the first non-peptide GLP-1 weight loss medication
  • Reduces appetite, snacking, and slows digestion
  • Daily pill that can be taken at any time with or without food
  • Switching from weight loss injections is possible
  • Most common side effects are feeling sick, being sick, constipation, and diarrhoea

Foundayo pill consultation prices

Doses
Price
0.8mg
 
– 1 month
 
Coming soon
TBD
2.5mg
 
– 1 month
 
Coming soon
TBD
5.5mg
 
– 1 month
 
Coming soon
TBD
9mg
 
– 1 month
 
Coming soon
TBD
14.5mg
 
– 1 month
 
Coming soon
TBD
17.2mg
 
– 1 month
 
Coming soon
TBD
PayPal Pay in 3 options available at checkout on all doses and bundles.

All prices include your treatment, online consultation, 24/7 aftercare, weight loss pack, and ongoing support. If treatment isn't suitable for you, you won't be charged.

How does the Foundayo pill work?

Foundayo works similarly to weight loss injections by binding to the receptors of the GLP-1 hormone, but is available as a once-daily pill rather than an injection. Foundayo suppresses your appetite, this makes it easier for you to eat fewer calories and lose weight.

diagram of a body explaining how wegovy works by reducing appetite and slowing down digestion

The biggest difference between Foundayo and weight loss injections is that Foundayo’s active ingredient, orforglipron, is absorbed via your digestive system, rather than under the skin.

More about how the Foundayo pill works

The Foundayo pill contains the active ingredient, orforglipron, which is a glucagon-like peptide-1 receptor agonist. It works by binding to the GLP-1 receptors in the brain to suppress your appetite and slow down the time it takes for food to leave your stomach, also known as gastric emptying. This means that food remains in your stomach for longer, so you feel full for longer and are less likely to snack between meals.

The way Foundayo works also makes it easier to follow a diet and exercise plan because it allows you to eat fewer calories and makes you feel less hungry. Like other GLP-1 medications, Foundayo also helps to regulate your blood sugar levels by releasing insulin after you eat.

Foundayo results: What to expect

The average weight loss on the highest 17.2mg dose of Foundayo is 12.4% over 72 weeks. However, everyone's weight loss journey will be different. In order for Foundayo to successfully help you lose weight, you should take it exactly as your doctor prescribes it, and it must be taken alongside a diet and exercise plan.

Months 1

Average weight loss of around 2%, possible side effects, and reduced appetite.

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Month 2

Average weight loss of 4%, side effects may return as dose increases.

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Month 3

Average 5% weight loss, stronger appetite reduction, and a potential return of side effects.

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Month 4

Average 7% weight loss, even greater appetite loss, and potentially to see some changes to body shape.

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Month 5

Average 8% weight loss, exercise may become easier.

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Months 6

10% average weight loss and maximum dose reached, so side effects may temporarily return, but weight loss may become more noticeable.

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More Foundayo results

In the ATTAIN-1 trial, the 36mg dose was shown to help:

  • 77.1% of people lose at least 5% of their starting body weight
  • 59.6% of people lose at least 10% of their starting body weight
  • 39.6% of people lose 15% or more of their starting body weight
  • 20.1% lose at least 20% of their starting body weight

There are two pharmaceutical forms of orforglipron: film-coated tablets and hard capsules. The film-coated tablets are available from 0.8mg to 17.2mg. The hard capsules (used during the ATTAIN trials) are available in doses from 1mg to 36 mg. The 17.2mg film-coated tablet dose has an equal effect to the 36mg hard capsule.

How to get the best results with Foundayo

Like all weight loss medications, Foundayo does not work on its own, and it will take effort and commitment from you to help you reach your weight loss targets.

It is important that you take the Foundayo pill exactly as your doctor tells you to, following the dosage schedule and any recommendations they make. You will also need to commit to making diet and lifestyle changes.

As Foundayo reduces your appetite, it will make it easier for you to eat less. This will help you move into a calorie deficit, which is where you burn more calories than you eat, and is a key part of weight loss. At the same time, you’ll also need to increase the amount of exercise you do to make sure you are burning more calories than you are consuming. These are key to ensuring Foundayo helps you successfully lose weight.

Foundayo pill vs Wegovy pill

Both the Foundayo pill and the Wegovy pill are oral GLP-1 tablets that are taken once daily. However, there are two key differences:

1. Active ingredients

Foundayo contains orforglipron, while Wegovy contains semaglutide, although they work in similar ways to help you lose weight by reducing your appetite, slowing digestion, and regulating your blood sugar levels.

2. How they are taken

Unlike the Wegovy pill, Foundayo offers more flexibility because it does not require you to fast before taking it or specify any food restrictions. However, in clinical trials, the Wegovy pill has a higher average weight loss of up to 17% over 64 weeks on the highest maintenance dose of 25mg compared to 12.4% at the maximum 17.2mg dose of Foundayo after 72 weeks.

Foundayo pill dosage

Foundayo pills are available in 6 strengths, which are gradually increased over a few months. The starting dose of Foundayo is 0.8mg per day. The dose is then increased every 30 days until you reach the maximum 17.2mg daily dose.

all doses of foundayo oral use film coated orforglipron tablets 0.8mg 2.5mg 5.5mg 9mg 14.5mg 17.2mg first six months of treatment

The available Foundayo doses are as follows:

  • Month 1 (starting dose) – 0.8mg
  • Month 2 – 2.5mg
  • Month 3 – 5.5mg
  • Month 4 – 9mg
  • Month 5 – 14.5mg
  • Maximum dose – 17.2mg

Not everyone will reach or need the maximum Foundayo dose. Instead, your doctor will monitor how your body responds to the medication, any side effects you get, and consider your weight loss goals to help you find the lowest effective dose. If you have tolerated your current dose well, you may consider increasing your dose after 30 days.

How to take Foundayo

Foundayo is taken once a day. You can take Foundayo with or without food as there are no fasting requirements when taking this weight loss pill.

You should swallow the tablet whole with water if needed. Do not break, crush, or chew the tablet.

time

Set and stick to a time

When taking your Foundayo pill

water

No need to fast

Swallow your pill whole with water

pill

Don't break your pill

Or cut or crush it

Ideally, you should take the pill at the same time every day to help keep your orforglipron levels stable, but when you take it is up to you. Pick a time that is most convenient for you and one that you will remember daily.

How quickly does Foundayo work?

The active ingredient in Foundayo, orforglipron, starts to suppress your appetite as soon as you take your first dose, however it can take several months to notice the full weight loss benefits of the medication.

How long can you take Foundayo for?

Foundayo is considered to be a long-term treatment for weight loss. In clinical trials, it has been studied for 72 weeks. Your doctor will discuss how long you should take Foundayo for, but it should be safe to continue taking for as long as it remains effective for you and whilst being supervised by a doctor.

Can you just stop taking Foundayo?

Yes, you can just stop it if you want to, but we’d recommend to speak to your doctor first if you are thinking about stopping Foundayo. Although it is possible to stop taking GLP-1 medications, like Foundayo, stopping suddenly can cause your appetite to return and increase the chance of weight gain. It can also cause your blood sugar levels to rise rapidly, especially if you have been taking orforglipron to manage type 2 diabetes.

Side effects of the Foundayo pill

Like all medications, the Foundayo pill can cause side effects. However, they are often mild and improve as your body gets used to the medication. In most cases, mild side effects are manageable at home.

Very common Foundayo side effects (may affect more than 1 in 10 people) are:

  • feeling sick (nausea)
  • constipation
  • diarrhoea
  • being sick (vomiting)
  • indigestion
  • stomach pain
nausea

Nausea

Affects 35% of people

constipation

Constipation

Affects 24% of people

diarrhoea

Diarrhoea

Affects 25% of people

constipation

Vomiting

Affects 24% of people

Serious side effects

The following serious side effects have been reported with Foundayo:

  • inflamed pancreas, which can cause severe pain in your stomach and back that does not go away
  • sudden changes in your vision
  • bowel obstruction causing severe stomach pain, bloating or swelling of the stomach, being sick, or not being able to poo or pass wind
  • severe constipation
  • serious allergic reaction, symptoms include swelling of your lips, eyes, tongue, or throat, difficulty breathing or swallowing, cold skin, feeling dizzy or weak
  • increased chance of food or liquid getting into your lungs during surgery or other procedures
  • severe diarrhoea or vomiting causing dehydration and potential kidney problems

If you are concerned about any of these side effects, contact your doctor for advice. If you think you may have a serious Foundayo side effect, get urgent medical help or, in an emergency, call 999 or get someone to take you to A&E.

Common Foundayo side effects

Common Foundayo side effects (may affect up to 1 in 10 people) include:

  • low blood sugar (hypoglycaemia) when Foundayo is taken with a sulfonylurea alone or in combination with up to 2 other type 2 diabetes medications
  • dizziness
  • headache
  • fast pulse
  • low blood pressure
  • bloating
  • burping
  • reflux or heartburn
  • gas
  • gallstones
  • hair loss
  • feeling tired
  • increased levels of pancreatic enzymes in your blood

Uncommon Foundayo side effects

Uncommon Foundayo side effects (may affect up to 1 in 100 people) are:

  • low blood sugar when orforglipron is taken without insulin or a sulfonylurea
  • unusual sense of taste
  • unpleasant or abnormal feeling when touched

What to do if you get side effects

Most Foundayo side effects are temporary and mild and will go away on their own as your body gets used to orforglipron. However, you can manage them at home by:

  • eating smaller more frequent meals – aim to eat 6 smaller meals over the course of the day rather than 3 large meals
  • choosing plain, bland foods – for example, rice and crackers, if you feel sick
  • drinking plenty of water to prevent dehydration, especially if you are sick, have diarrhoea or constipation, or are getting headaches
  • getting plenty of rest until you feel better
  • slowly introducing fibre into your diet, especially if you get diarrhoea
  • taking over-the-counter painkillers, such as paracetamol or ibuprofen, to manage headaches

If you get any side effects that get worse, do not improve, or are difficult to manage, contact your doctor for more advice. If you have severe stomach pain, are vomiting and cannot keep water down, or feel very unwell, get urgent medical help.

Who can take the Foundayo pill

The Foundayo pill may be right for:
  • people who have a BMI of 30 or more
  • people who have a BMI of 27 or more and a weight-related health condition, like high blood pressure
  • people who are already receiving weight loss treatment and want to switch

The Foundayo pill is suitable for adults who have a body mass index (BMI) of 30 or above or 27 or above with weight-related health conditions, such as prediabetes, high blood pressure, or obstructive sleep apnoea, though sometimes our doctors may consider starting this treatment off-label if you would safely benefit from it.

Who should not use the Foundayo pill?

The Foundayo pill may not be suitable for everyone. There are some medical conditions or medications that may make Foundayo unsuitable for you, as they may make orforglipron less effective or potentially unsafe.

Do not take Foundayo if you are allergic to orforglipron or any of the other ingredients listed in the medication, or if you are pregnant or breastfeeding.

You will also need to tell your doctor before taking Foundayo if you:

  • have or have ever had pancreatitis
  • are using a sulfonylurea and/or insulin for diabetes
  • have severe problems with food digestion or food staying in your stomach for longer than usual (severe gastroparesis)
  • have kidney problems because some Foundayo side effects, like feeling and being sick and diarrhoea, can cause dehydration
  • are taking medication to manage high blood pressure
  • have gallbladder problems
  • have a problem with your eyes or vision
  • are due to have surgery and require anaesthesia
  • have or have had severe heart failure

You should also let the doctor know before starting Foundayo about any prescribed, over the counter, or herbal medicines you are taking. Some medications can increase or decrease the concentration of orforglipron in your system, while Foundayo may also affect other medications. Tell the doctor if you are taking any of the following:

  • clarithromycin to treat bacterial infections
  • itraconazole or ketoconazole to treat fungal infections
  • ritonavir or telaprevir to treat viral infections
  • carbamazepine to treat seizures
  • bosentan for pulmonary hypertension
  • efavirenz to treat viral infections
  • rifampicin to treat bacterial infections
  • phenytoin to treat seizures
  • St. John’s wort
  • simvastatin to lower cholesterol
  • rosuvastatin for lowering cholesterol
  • topotecan to treat certain cancers
  • oral contraceptives – you will need to use a barrier method, such as condoms, or a non-oral contraception method for 30 days after starting Foundayo and for 30 days after each dose increase

Alternatives to Foundayo

Although the Foundayo pill is an effective weight loss pill, it may not be right for everyone. We have several weight loss alternatives available, including injections or pills, depending on your preference:

Foundayo Wegovy Wegovy Mounjaro Nevolat Mysimba Orlistat
Type Pill Pill Injection Injection Injection Pill Pill
Active ingredient Orforglipron Semaglutide Semaglutide Tirzepatide Liraglutide Bupropion & naltrexone Orlistat
How it works Reduces appetite Reduces appetite Reduces appetite Reduces appetite Reduces appetite Reduces appetite Prevents fat absorption
How often to take it Daily Daily Weekly Weekly Daily Twice daily Up to 3 times daily with meals

Foundayo

Type Pill
Active ingredient Orforglipron
How it works Reduces appetite
How often to take it Daily

Wegovy

Type Pill
Active ingredient Semaglutide
How it works Reduces appetite
How often to take it Daily

Wegovy

Type Injection
Active ingredient Semaglutide
How it works Reduces appetite
How often to take it Weekly

Mounjaro

Type Injection
Active ingredient Tirzepatide
How it works Reduces appetite
How often to take it Weekly

Nevolat

Type Injection
Active ingredient Liraglutide
How it works Reduces appetite
How often to take it Daily

Mysimba

Type Pill
Active ingredient Bupropion & naltrexone
How it works Reduces appetite
How often to take it Twice daily

Orlistat

Type

Pill

Active ingredient

Orlistat

How it works

Prevents fat absorption

How often to take it

Up to 3 times daily with meals

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Foundayo vs weight loss injections

Compared to the most popular weight loss injections available, Foundayo is a little less effective for weight loss, but it offers a needle-free alternative for people who are uncomfortable with self-injecting.

Mounjaro and Wegovy injections

  • 21 to 22.5% average weight loss on the maximum maintenance dose
  • once-weekly injections
  • can be taken at any time of the day
  • most common side effects are feeling sick, being sick, headaches, constipation
  • can be taken with or without food

Nevolat injections

  • average starting weight loss of 8%
  • daily injections
  • can be taken at any time of the day
  • most common side effects are feeling sick, being sick, headaches, constipation
  • can be taken with or without food

Foundayo

  • 12.4% average weight loss
  • daily pill
  • can be taken at any time of the day
  • most common side effects are feeling sick, being sick, headaches, constipation
  • can be taken with or without food

Foundayo vs other weight loss pills

Foundayo is an effective weight loss pill that has the added advantage that it can be taken at any time of the day without the need to fast.

Wegovy pill

  • 17% average weight loss
  • reduces appetite
  • must be taken on an empty stomach and 30 minutes before eating or drinking

Orlistat

  • on 120mg, 37% of people lost at least 5% of their initial body weight
  • prevents dietary fat absorption
  • must be taken with a meal that contains fat

Mysimba

  • 8% average weight loss
  • reduces appetite
  • needs to be taken with food

Foundayo

  • 12.4% average weight loss
  • reduces appetite
  • can be taken at any time of the day, with or without food

FAQs

Will Foundayo be available on the NHS?

It is not yet known whether Foundayo will be available on the NHS. However, it was approved by the MHRA on 10 August 2026, meaning it will be available for weight management in the UK. Now, the National Institute for Health and Care Excellence (NICE) will need to assess Foundayo and decide whether it should be made available on the NHS.

If NICE approves Foundayo, it can take up to 3 months to become available through the NHS. So, it is unlikely to be available on the NHS until late 2026 or early 2027 at the earliest.

Is Foundayo better than Mounjaro or Wegovy?

No, in terms of weight loss, Foundayo is not better or more effective than Mounjaro or Wegovy, which can result in an average weight loss of 21 to 22.5% compared to 12.4% with Foundayo. However, Foundayo is a once-daily pill that allows for flexible dosing because it does not require fasting, unlike the Wegovy pill, and does not require injecting. Which is better for you will depend on your personal circumstances, preferences, and current health conditions and medications.

Is orforglipron (Foundayo) safe?

Foundayo is considered a safe weight loss medication and has been approved in the US by the Food and Drug Administration (FDA) and by the MHRA in the UK. Phase 3 clinical trials have demonstrated that orforglipron is both safe and effective for long-term weight management.

What if I’m not losing weight with the Foundayo pill?

If you are not getting the results you expected on the Foundayo pill, there could be several reasons for this. The first reason is that you may not have made the necessary lifestyle changes needed for orforglipron to be effective. Foundayo does not work on its own, and you will need to reduce your calorie intake and increase the amount of exercise you do.

Secondly, you may not have reached the most effective dose yet. If you have only recently started Foundayo, it can take several weeks or months to notice the full benefits of the medication. It is important to be patient both with yourself and the medication, and allow a sufficient amount of time for Foundayo and your lifestyle changes to take effect.

If you are still concerned that you are not losing weight on Foundayo, speak to your doctor for more advice.

Sources

Medically reviewed by

babak-updated-roundpng.png Dr Babak Ashrafi

Babak graduated from King’s College London in 2003. Since joining ZAVA, Babak has been instrumental in the development and research of new services. In particular, his work has resulted in the launch of an ‘online-doctor first’ – the ZAVA PrEP service, as well as launching ZAVA's Weight Loss service.

Last reviewed: 13 Aug 2026

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Dr. Anca Vasilis-Peter,  Endocrinologist & Nutrition Specialist

Dr. Anca Vasilis-Peter

Endocrinologist & Nutrition Specialist

Dr. Kathryn Basford, Clinical Lead at ZAVA

Dr. Kathryn Basford

GP & Doctor Team Lead

Fenja Nolte, Nutritionist at ZAVA

Fenja Nolte

Nutritionist

Meet our team

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