Foundayo pill dosage guide

Foundayo is a branded form of orforglipron, a daily weight loss pill manufactured by Eli Lilly, the same company that produces Mounjaro. Foundayo is a non-peptide small-molecule oral glucagon-like peptide-1 (GLP-1) receptor agonist that is taken every day with or without food to help you lose weight.

In this guide, we explain the available doses, the titration schedule, what to do if you miss a dose, and how Foundayo pill doses compare with other GLP-1 tablet doses.

Foundayo is available in 6 doses, ranging from 0.8mg to 17.2mg per day. You’ll begin at the lowest dose and gradually increase it every month until you reach the maximum maintenance dose or the dose that works best for you.

If your body tolerates orforglipron well, it will take 6 months to reach the maintenance dose. Following the dosing schedule helps your body get used to the active ingredient and reduces the chance of side effects.

Foundayo is taken once daily. It can be taken at any time of the day as long as it is taken at the same time each day to keep the medication at a consistent level in your body. Foundayo also has no food or water restrictions, so you can take it with or without food.

The Foundayo pill dosage increases gradually over the first 6 months of treatment. This is called titration and helps to reduce the very common gastrointestinal side effects associated with taking Foundayo, such as feeling sick (nausea), being sick (vomiting), diarrhoea, and constipation.

The Foundayo dosing schedule looks like this:

The Foundayo dosing schedule is a guide. Although you cannot increase your dose any sooner than 1 month, you can remain on a lower dose to help your body adjust or if you are getting side effects. You are most likely to get Foundayo side effects at the start of treatment and after each dose increase.

Can I stay on a low dose of Foundayo?

Yes, it is possible to remain on a low dose of Foundayo. Your doctor may advise staying on a lower dose if it is helping you to meet your weight loss goals, is managing your appetite well, or you are getting side effects. Not everyone who takes Foundayo will need to reach the maximum 17.2mg dose.

Foundayo does not have any food or drink restrictions, unlike other GLP-1 weight loss pills, such as the Wegovy pill, making it a more convenient and flexible option for some people.

How to take Foundayo correctly:

1. Choose a time of day to take your Foundayo tablet that is convenient for you – you should take the tablet at the same time every day.
2. Swallow the tablet whole, do not break, crush, or chew it. You can take it with or without food.
3. Do not take more than 1 tablet per day.

If you miss a Foundayo pill, take it as soon as you remember, but do not take more than one dose per day. It is important that you do not take a double dose to make up for a forgotten Foundayo dose as this can increase the chance of side effects.

If you missed:

• 4 Foundayo pill (4 days), stay on your current dose
• 5 to 10 Foundayo pills (5 to 10 days), you will need to go down at least one dose – for example, if you have been taking 9mg per day but have missed 7 pills, you will need to go down to 5.5mg per day
• more than 10 pills or days, you will need to start the dosing schedule again from the lowest 0.8mg daily dose

If you have missed any Foundayo pills and are unsure about what to do, speak to your doctor or pharmacist for advice.

The starting dose of Foundayo is 0.8mg per day. You will usually remain on this dose for at least 1 month before increasing to the next dose, followed by a series of step-up doses. Starting your treatment on the lowest dose gives your body the chance to get used to orforglipron and minimises the chance of gastrointestinal side effects.

Side effects are most common when you start taking Foundayo because the medication changes how food moves through your digestive system and slows down its movement through your stomach. Your body needs time to adjust to these changes, and starting on a low dose of orforglipron can help.

The maintenance dose of Foundayo is 17.2mg per day and this is the only maintenance dose available. However, you can remain on a lower dose if it is effective for you. In clinical trials, the maximum dose of Foundayo has produced the greatest weight loss results with people losing on average 12.4% of their starting body weight after 72 weeks compared to 0.9% on a placebo.

When you increase the Foundayo dose, the amount of orforglipron you take will also increase. This means you may notice that its effects become stronger, but so can the side effects as your body adjusts to the new dose.

As your Foundayo dose increases, you may notice that you:

• feel less hungry between meals
• feel full more quickly when eating a meal
• snack less and have fewer cravings
• find it easier to maintain a calorie deficit
• have less food noise
• get a return of or more intense side effects

Both Foundayo and the Wegovy pill are examples of daily oral GLP-1 receptor agonists that have been approved for weight loss in the UK. They work in the same way by mimicking the hormone GLP-1 to suppress your appetite and slow digestion. However, they contain different active ingredients and are available in different strengths which are not equivalent.

Foundayo may be right for you if you are eligible for weight loss treatment and have a preference for a daily pill that has a more flexible dosing regimen. This makes Foundayo a good alternative for people who find it difficult to fast or cannot commit to the more rigid Wegovy pill schedule or anyone who feels uncomfortable with injections.

You may be suitable for Foundayo if you have a body mass index (BMI) of:

• 30 or above
• 27 to 30 with a weight-related health condition, such as prediabetes, high blood pressure, high cholesterol, or obstructive sleep apnoea

You might choose Foundayo if you:

• want a more convenient dosing regimen – you can take Foundayo with or without food as it remains stable in the stomach and does not need a special coating to help its absorption
• are uncomfortable with needles or injections – Foundayo is a daily pill that is swallowed rather than a weekly or daily injection
• are allergic to or cannot tolerate semaglutide – if you have had side effects while taking the Wegovy pill or the Wegovy injection, Foundayo may be a more suitable option as it has has a different active ingredient

If you think Foundayo may be the right weight loss treatment for you, start a consultation with one of our doctors today.

• Foundayo 14.5 mg film-coated tablets, electronic medicines compendium (emc) [accessed 24 August 2026]
• Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity, The New England Journal of Medicine (NEJM) [accessed 24 August 2026]
• Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment, The New England Journal of Medicine (NEJM) [accessed 24 August 2026]
• Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen, electronic medicines compendium (emc) [accessed 24 August 2026]